Long term effect of ovarian surgery on ovarian reserve and fertility
Research type
Research Study
Full title
The long-term impact of ovarian surgery on ovarian reserve and reproductive performance: a longitudinal cohort study
IRAS ID
202668
Contact name
Saad Amer
Contact email
Sponsor organisation
Derby Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 5 months, 26 days
Research summary
Ovarian procedures including excision of cysts (cystectomy) and removal of one ovary (oophorectomy) are very commonly performed in Gynaecological practice worldwide for various disorders. Although, there has been a growing concern that these procedures could be damaging to the ovary, very little is known about their impact on ovarian function and fertility potential. One of the tests currently undertaken to investigate the ovarian function is called ovarian reserve, which refers to the functional reproductive potential of the ovary. It reflects the number and quality of the remaining eggs within the ovary at any given time. Currently, the blood level of anti-müllerian hormone (AMH) is widely accepted as a reliable marker of ovarian reserve.The aim of the proposed project is to study the long-term effect of ovarian surgery on the blood level of AMH. This will be achieved by inviting women who had undergone either ovarian cystectomy or excision of one ovary within the last 10 years to be tested for their ovarian reserve. The results will be compared with an age and weight-matched group of women without any previous surgery. We will also compare the results with an age and weight-matched group of women with ovarian cysts, which have not been treated surgically.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
16/EM/0244
Date of REC Opinion
7 Jul 2016
REC opinion
Further Information Favourable Opinion