Long- and Short-Term Outcomes of Patients’ Mitral Valve Repair Surgery
Research type
Research Study
Full title
Long- and Short-Term Outcomes of Patients’ Mitral Valve Repair Surgery
IRAS ID
269148
Contact name
Jane Allen
Contact email
Sponsor organisation
Newcastle University
Duration of Study in the UK
0 years, 8 months, 28 days
Research summary
Within the heart, the mitral valve is an important valve controlling blood flow from the left atrium to the left ventricle. The valve is structured to prevent back flow (regurgitation) so blood can efficiently be pumped from the left ventricle around the body. However, due to many factors, the valve can degenerate and cause this back flow, termed mitral regurgitation, eventually leading to heart failure.
The severity of regurgitation can be graded using echocardiography (none, mild, moderate or severe). National guidelines determine the need for repair surgery on the mitral valve based on the severity of this regurgitation along with other factors, such as symptoms and the presence of other cardiac conditions. Surgery for mitral regurgitation is the second most common valve surgery in Europe.
Numerous large centre studies have been done around the world to assess how successful this type of surgery is. This study will assess the outcomes of mitral valve repair surgery for the York demographic across four surgical centres.
A recent internationally recognised study compared the current method of repair to an emerging method with specific criteria to assess outcomes of surgery. It followed up patients for 12 months. A further follow up study assessed these patients up to 5 years. This study will use those outcomes in this study along with follow up periods to ensure consistency in methods. This includes survival, the need for further mitral valve surgery/reoperation, grading of mitral regurgitation after surgery, freedom from symptoms and improved left ventricular ejection fraction % (an echocardiography measurement to assess heart function).
REC name
North East - York Research Ethics Committee
REC reference
19/NE/0292
Date of REC Opinion
10 Sep 2019
REC opinion
Favourable Opinion