LOGIC Study V1.0 [COVID-19]
Research type
Research Study
Full title
LOGIC (LongItudinal Study of COVID-19): Symptoms, Virology & Immunity
IRAS ID
282718
Contact name
Adam Finn
Contact email
Sponsor organisation
University of Bristol
ISRCTN Number
ISRCTN44324934
Duration of Study in the UK
1 years, 8 months, 12 days
Research summary
COVID-19 is the most significant infectious epidemic of modern times, currently in April 2020 killing thousands of people around the world every day. Strategies to prevent spread of infection include social distancing and the development of a vaccine. These require detailed understanding of the disease. There are some basic questions about COVID-19 to which we urgently need answers, including: 1) How often are COVID-19 tests negative during the infection or positive without showing any signs of illness? 2) Can we reliably test for immunity to COVID-19 after infection or vaccination with a blood test? 3) How long after infection does immunity last? To answer these questions, we need to understand the links between the symptoms of COVID-19, swab tests for infection and blood tests for immunity. We will study all these things in doctors and nurses working in the Emergency Department of Bristol Royal Hospital for Children over a 3-month period starting in April 2020. Staff who agree to participate will fill out an online symptom dairy every day. Twice a week, participants will swab their own nose and throat and provide a saliva sample, which we can test for COVID-19 in the laboratory. Blood samples will be taken from participants at the beginning of the study, at 6-week intervals for 18 weeks, and again after a year. The main advantage of studying doctors and nurses is that they can easily and safely obtain samples from their own nose/throat/mouth. After the study has been completed, we will analyse the results and publish them in a scientific journal. This study will help us provide answers to the fundamental questions about COVID-19 infection that are needed to inform public health measures such as social distancing and vaccination.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
20/YH/0148
Date of REC Opinion
17 Apr 2020
REC opinion
Favourable Opinion