LOCHINVAR-K
Research type
Research Study
Full title
LOCHINVAR-K – LOnger-term effects of SARS-CoV-2 INfection on blood Vessels And blood pRessure - Kids
IRAS ID
304319
Contact name
Angela Lucas-Herald
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Research Summary
The COVID-19 pandemic is the biggest medical challenge in decades. Individuals with pre-existing cardiovascular diseases have a higher risk of severe disease and death from COVID-19. The SARS-CoV-2 virus causes infection by targeting ACE2 a receptor which is found on the walls of the cells lining the lungs and the blood vessels leading to injury. There are concerns that after recovery from COVID-19, the damage sustained from these cells may have long term consequences including hypertension. This study (LOCHINVAR-K) is based on the pilot study “COVID-19 blood pressure endothelium interaction study” (OBELIX), which found that adults with normal blood pressure at the time of hospital admission with COVID-19 showed an 8.6 mmHg higher blood pressure ≥12 weeks after recovery, compared to a group without COVID-19. The burden of hypertension, as a result of the pandemic is unknown and a greater understanding of COVID-19 impact on blood pressure and its underlying mechanisms is urgently needed. It is not clear what the effects of COVID-19 might be on the vasculature in children. LOCHINVAR-K will therefore extend the OBELIX study aiming to establish if COVID-19 increases the risk of developing hypertension in children and young people and investigating underlying mechanisms through detailed measurements of blood pressure and vascular phenotyping.
Summary of Results
This study sought to look at the effects of COVID-19 on blood vessel health of children and young people. There was insufficient interest in the study to be able to conduct any meaningful analysis.
REC name
West of Scotland REC 5
REC reference
21/WS/0168
Date of REC Opinion
27 Jan 2022
REC opinion
Further Information Favourable Opinion