Local Anaesthetics

• Research type

  Research Study

• Full title

  Comparison of efficacy of concentration with volume of local anaesthetics in femoral-sciatic blocks for total knee replacement

• IRAS ID

  17267

• Sponsor organisation

  Conwy and Denbighshire NHS Trust

• Eudract number

  2009-011233-27

• ISRCTN Number

  N/A

• Clinicaltrials.gov Identifier

  N/A

• Research summary

  The use of regional blocks has the advantage of reducing the use of painkillers such as opiates during and post surgery. This reduces the side effects such as respiratory depression and drowsiness associated with opiates. We were always taught that the total dose of local anaesthetics matter more than the variation in volume and concentration, however there is very research showing that is really the case in regional blocks. Most of the research was in spinal anaesthesia which is different from regional blocks.

• REC name

  West Midlands - Edgbaston Research Ethics Committee

• REC reference

  09/H1208/29

• Date of REC Opinion

  10 Sep 2009

• REC opinion

  Further Information Favourable Opinion