LIving BEtteR with asThma studY (LIBERTY)
Research type
Research Study
Full title
LIving BEtteR with asThma studY (LIBERTY)
IRAS ID
335919
Contact name
Anna Freeman
Contact email
Sponsor organisation
UHS
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
The burden of poor asthma control remains high. Many patients with asthma remain symptomatic despite optimised treatment including targeted biologic therapies. Well-controlled asthma is heavily reliant on ongoing medical treatment, with potential for medication side effects. However, it is increasingly recognised that problematic asthma is a multidimensional state comprising numerous treatable traits that merit targeted approaches. Ideally these approaches should facilitate self-management approaches that support patients’ behaviour change, optimise their psychological wellbeing and deliver a goal of patient empowerment. Collectively addressing pulmonary, extrapulmonary and behavioural/ psychological treatable traits in such an integrated way has potential to significantly impact the burden of asthma at an individual patient level. We hypothesis that a multimodal intervention comprising a structured responsive exercise training programme (SRETP) and psychological/behavioural support through healthy conversations (HC), breathing retraining and dietary support for patients with difficult asthma
i. is safe and acceptable in this patient group.
ii. will increase exercise capacity and quality of life.
iii. may help identify potential biological mechanisms that mediate impact of multimodal lifestyle interventions. We are co-developing with patients a 24 week intervention to be delivered in the community comprising prescribed exercise, breathing retraining, dietary support and behaviour change support. We will assess patients at baseline, 6 and 12 months in person, with blood and urine sampling and lung function testing, and virtually and 3 and 9 months to assess response and whether it results in sustained behaviour change.REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
24/EM/0184
Date of REC Opinion
16 Oct 2024
REC opinion
Further Information Favourable Opinion