LISA in late preterm/ term infants
Research type
Research Study
Full title
Less Invasive Surfactant administration in late preterm or early term born infants
IRAS ID
324607
Contact name
Theodore Dassios
Contact email
Sponsor organisation
King's College Hospital NHS Foundation Trust
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
2 years, 4 months, 0 days
Research summary
We want to study a gentler way of giving surfactant (a substance that helps with breathing) to babies who have trouble breathing after birth. This method is called Less Invasive Surfactant Administration (LISA). It avoids using a machine to push air into the baby's lungs, which can sometimes cause harm.
Previous research has shown that using LISA with very premature babies helps them breathe better and reduces the need for breathing machines. Now, we want to see if it can also benefit babies who are born less premature (34-36 weeks) and at term (37-38 weeks). These babies can also have breathing problems, and using LISA might help them without the risks of using invasive breathing machines.
We plan to use a treatment called high-flow nasal cannula (HFNC), which gives extra oxygen through the baby's nose. This has worked well for babies born prematurely reducing the need for invasive ventilation. Combining HFNC with LISA in this group of infants could be helpful, but no one has studied this before.
Our aim is to find out if using LISA with HFNC for these babies can reduce the time they need a breathing machine for. We'll measure how well the babies are doing and check if there are any changes we need to make to the LISA technique for this group of babies. Additionally, we want to identify babies who might not respond well to this treatment.
REC name
London - Hampstead Research Ethics Committee
REC reference
24/PR/0431
Date of REC Opinion
24 Apr 2024
REC opinion
Further Information Favourable Opinion