Lipoprotein Lipase Deficiency (LPLD) Patient Case Examples
Research type
Research Study
Full title
Lipoprotein Lipase Deficiency (LPLD) Patient Case Examples
IRAS ID
173627
Contact name
Rachel Malone
Contact email
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Lipoprotein Lipase Deficiency (LPLD) is a rare genetic disorder with an estimated prevalence of 1-2 people per million. LPLD is associated with acute pancreatitis, which is a serious condition where the pancreas becomes inflamed over a short period of time. Most people with acute pancreatitis improve within a week, but severe cases can have serious complications requiring admission to Intensive Care Units, and can even be fatal. Pancreatitis attacks can only be limited by lowering plasma triglyceride levels, where patients have to maintain an ultra-low fat diet. Despite maintaining this diet, almost 30% of patients with LPLD develop pancreatitis. Given the low prevalence, very little is known regarding the overall burden of illness and impact that LPLD has on patients' quality of life, as well as that on their families.
The objective of this research is to produce 3 anonymised written patient case examples to provide a detailed picture of the impact LPLD has on patients and those surrounding them, clearly demonstrating the challenges the condition brings in daily life. The research is solely comprised of qualitative patient and family member interviews.
REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
16/YH/0220
Date of REC Opinion
27 May 2016
REC opinion
Favourable Opinion