LINKED

• Research type

  Research Study

• Full title

  Investigation of the impact of germ Line variation IN the K channel KCNJ5 on the rEnin-angiotensin axis and alDosterone release in human subjects

• IRAS ID

  139745

• Contact name

  Kevin O'Shaughnessy

• Contact email

  kmo22@medschl.cam.ac.uk

• Sponsor organisation

  Cambridge University Hospitals NHS Foundation Trust and University of Cambridge

• Research summary

  Recently, studies have shown that a few DNA mutations in the potassium channel KCNJ5 gene can explain abnormal aldosterone levels (primary hyperaldosteronism, PA) and a subset of aldosterone-producing adenomas, the most frequent secondary cause of arterial hypertension. The main purpose of this trial is to determine if a novel set of genetic mutations, which are different to those previously reported, in the KCNJ5 gene will also affect release of aldosterone and hence increase circulating aldosterone levels and blood pressure.

• REC name

  East of England - Cambridge Central Research Ethics Committee

• REC reference

  14/EE/0052

• Date of REC Opinion

  1 Apr 2014

• REC opinion

  Further Information Favourable Opinion