Lifestyle Intervention and Hypertrophic Cardiomyopathy
Research type
Research Study
Full title
Clinical and genetic determinants of disease progression and response to lifestyle intervention in patients with hypertrophic cardiomyopathy
IRAS ID
252015
Contact name
Djordje Jakovljevic
Contact email
Sponsor organisation
Mr
Duration of Study in the UK
3 years, 4 months, 28 days
Research summary
The overall aim of this project is to establish potential benefits of a lifestyle intervention incorporating physical activity and dietary supplementation with inorganic nitrate in patients with hypertrophic cardiomyopathy (HCM). HCM is the most common genetic cardiovascular disease with a broad spectrum of disease severity. Moderate-intensity exercise training is associated with a significant increase in exercise tolerance, but appear to have limited effect on measures of cardiac morphology or function in patients with hypertrophic cardiomyopathy. Dietary supplementation with inorganic nitrate (i.e. concentrated nitrate-rich beetroot juice) improves exercise capacity, vasodilatation and cardiac output reserves while reduces arterial wave reflections, which are linked to left ventricular diastolic dysfunction and remodelling. The present study proposes a pilot randomized controlled trial to determine the efficacy of physical activity and dietary supplementation with inorganic nitrate intervention in HCM patients. The Aim is to examine whether this lifestyle intervention improves functional capacity, clinical phenotypic characteristics, and quality of life in patients with HCM.
REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
18/NE/0318
Date of REC Opinion
14 Nov 2018
REC opinion
Further Information Favourable Opinion