LFP-DYT
Research type
Research Study
Full title
Local field potentials in dystonia (LFP-DYT) – Assessment of the reproducibility and translational aspects of local field potential analysis in globus pallidus interna deep brain stimulation for dystonia
IRAS ID
337426
Contact name
David RM Ledingham
Contact email
Sponsor organisation
Newcastle Upon Tyne NHS Foundation Trust
Clinicaltrials.gov Identifier
A 1864820, Medtronic MDT number
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
This study intends to investigate the potential benefits of local field potential (LFP) monitoring in patients who have had deep brain stimulation (DBS) for dystonia. The Medtronic Percept device is the current standard of care for deep brain stimulation. It can deliver stimulation as well as detect LFPs. In Parkinson's disease, detecting LFPs can help clinicians deliver stimulation more effectively. This has not yet been studied in dystonia. In patients who are already due to have DBS surgery through the NHS pathway with the Medtronic system, we would like to monitor them more carefully and take more readings in the first year post-surgery to learn more about the pattern of LFPs in dystonia and assess if LFP detection can help guide stimulation for patients with dystonia, and then lead to improved outcomes from DBS.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
24/EM/0246
Date of REC Opinion
26 Nov 2024
REC opinion
Further Information Favourable Opinion