Leukaemia Model in Humanized Mice Version 1
Research type
Research Study
Full title
Establishment of a Chronic Lymphocytic Leukaemia Model in Humanized Mice
IRAS ID
181517
Contact name
Sze Ki Carol Leung
Contact email
Sponsor organisation
University College London
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
Chronic Lymphocytic Leukaemia (CLL) is the most common leukaemia in adults in the Western countries and accounts for nearly one third of the newly diagnosed leukaemia cases. The immune system is able to prevent and control cancer development by killing cancer cells. However, cancer cells can prolong their survival by taking over a normal immune system. T cells are a kind of immune cell that plays an important role in cancer surveillance in general, but its role in the development and control of CLL is not well understood. This study aims to establish a CLL model in mice engineered to have a human immune system, so called humanized mice. This will act as an important tool to address the role of T cells in CLL disease development. The results will help us to design better treatments to target the immune system against CLL. In addition, the established CLL model will be a valuable tool in testing different therapies against the disease. In conclusion, the data will enhance the understanding of the immune control against CLL, advance the treatment of this disease and eventually benefit the patients.
REC name
London - Fulham Research Ethics Committee
REC reference
15/LO/1806
Date of REC Opinion
23 Nov 2015
REC opinion
Unfavourable Opinion