Left bundle branch pacing in Atrioventricular block
Research type
Research Study
Full title
Protection of Cardiac Function with Left Bundle Branch Pacing in Patients with Atrioventricular Block (OptimPacing)
IRAS ID
300137
Contact name
Zachary Whinnett
Contact email
Sponsor organisation
The First Affiliated Hospital, Nanjin Medical University
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
JX233C202103, Funder Reference: Grant of New Technology Project from Finance Department; JSPH-MA-2020-3, Funder Reference: Grant of Clinical Ability Improvement Project from Jiangsu Province Hospital
Duration of Study in the UK
4 years, 5 months, 25 days
Research summary
Pacemakers are small electrical devices that are implanted to prevent the heart from going too slow. Usually this involves putting a lead in the top right (right atrium) and bottom right (right ventricle) chambers of the heart. Right ventricular pacing (RVP) can lead to uncoordinated muscle movements of the bottom chambers of the heart (ventricles) which increases the risk of developing weakness of the heart muscle, irregular heart rates (atrial fibrillation) and death. Pacing via the native conduction system via the left bundle branch may avoid these problems associated with right ventricular pacing.
In this international, multi-centre research study, participants will be randomised to either RVP or left bundle branch pacing (LBBP). We will follow them up with regular heart scans, tracings, quality of life questionnaires, pacemaker checks, blood tests and a 6 minute walk test to objectively see how they are progressing.
The purpose of this study is to determine whether LBBP is superior in preserving the pump function of the heart compared to RVP and to assess the feasibility and long-term safety of LBBP in patients with slow heart rates.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
22/YH/0113
Date of REC Opinion
31 May 2022
REC opinion
Favourable Opinion