Left Atrial Appendage Occlusion Study III (LAAOS III)

• Research type

  Research Study

• Full title

  Left Atrial Appendage Occlusion Study III (LAAOS III)

• IRAS ID

  155035

• Contact name

  Prakash Punjabi

• Contact email

  p.punjabi@imperial.ac.uk

• Sponsor organisation

  Population Health Research Institute

• Clinicaltrials.gov Identifier

  NCT01561651

• Duration of Study in the UK

  6 years, 0 months, 30 days

• Research summary

  The primary objective is to examine the impact of left atrial
  appendage occlusion on the incidence of stroke or systemic
  arterial embolism in patients with atrial fibrillation
  undergoing cardiac surgery over the duration of follow-up.
  The secondary objectives over the duration of follow-up
  (unless otherwise specified) are:
  1) To determine total mortality
  2) To determine post-operative safety outcomes (chest tube
  output in the first 24 hours post-surgery, post-operative
  re-exploration for bleeding in the first 48 hours postsurgery,
  and 30-day mortality)
  3) To determine the incidence of re-hospitalization for heart
  failure
  4) To determine the incidence of major bleeding
  5) To determine the incidence of myocardial infarction

• REC name

  London - Harrow Research Ethics Committee

• REC reference

  15/LO/0769

• Date of REC Opinion

  2 Jul 2015

• REC opinion

  Further Information Favourable Opinion