LEAPS V1.0
Research type
Research Study
Full title
Longitudinal Evaluation of Affective Psychoses - Symptoms (LEAPS) V1.0
IRAS ID
136242
Contact name
Iain Macmillan
Contact email
Sponsor organisation
Northumberland, Tyne and Wear NHS Foundation Trust
Research summary
The main research question is; what are the predictive factors for development of affective psychosis compared to non-affective psychosis? The secondary research question is; are there enough predictive factors to enable us to develop a reliable, valid instrument to detect affective and non-affective psychoses as early as possible?
Affective psychosis involves episodes of low or elevated mood in addition to psychotic symptoms. It affects approximately 40% of people presenting with a first episode of psychosis and accounts for a substantial proportion of the global burden of illness in young people. Unstable symptoms mean it is often unclear initially which psychosis patients are suffering from. This can result in inappropriate treatment being given and further episodes of psychosis which can worsen multiple functional aspects including brain function. Early identification of the different types of psychosis would therefore be highly beneficial to patients.
Our aim is to conduct a pilot, observational study examining the course and outcomes of the affective psychoses and exploring the development of personalised treatment options. Participants will be identified through routine referral meetings of NHS Early Intervention in Psychosis (EIP) teams. Patients aged 16 -25 years under the care of an EIP team will be approached.
Routine and additional assessments will be used to obtain a detailed clinical and social history at 0 months. Participants can also take part in the sub-study involving a semi-structured interview to discuss their symptoms and social factors in more detail. After one year, a diagnostic assessment will be conducted to establish if the participant has an affective or non-affective psychosis. It is hoped that results could identify early indicators of affective psychoses and aid the development of an instrument which can be used to help differentiate between the groups as they enter services.
There is no specific funding for this study.
REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
14/NE/1092
Date of REC Opinion
29 Sep 2014
REC opinion
Further Information Favourable Opinion