LATTE: Long-term Anastrozole vs Tamoxifen Treatment Effects
Research type
Research Database
Full title
LATTE: Long-term Anastrozole vs Tamoxifen Treatment Effects. An epidem
IRAS ID
143200
Contact name
Jack Cuzick
Contact email
Research summary
LATTE: Long-term Anastrozole vs Tamoxifen Treatment Effects
REC name
London - South East Research Ethics Committee
REC reference
09/H1102/1+5
Date of REC Opinion
21 Jan 2014
REC opinion
Favourable Opinion
Data collection arrangements
The LATTE study is the long term follow up of participants in the precursor trial called ATAC. In the ATAC trial approximately 5000 participants, previously found to have early stage breast cancer, were treated with either tamoxifen or anastrozole for a period of 5 years, and were subsequently monitored for a further 5 years. We believe it is important to continue to follow up these participants to gather information on how successful these drugs are at preventing breast cancer recurrence in the long term, but also, very importantly, on how safe it is to use these drugs for this purpose. LATTE therefore began in 2009 to continue following up these participants and we hope to continue the LATTE study as it has done for the last five years. Participants consented to being followed up in the long term but are aware that they can withdraw consent at any time without their care being affected in any way.
We hope to continue to gather information on important events like breast cancer recurrences, breast cancers on the opposite breast, fractures requiring hospitalisation, cardiovascular events like heart attacks and cerebrovascular events like strokes and deaths.
Data collection will continue to take place at sites that participated in ATAC once the appropriate agreements are in place, e.g. a Data Supply Agreement (DSA). Follow up information will be entered directly into the database via a secure and encrypted website. We also use NHS registries to supplement the database.Research programme
The Long Term Follow up of the ATAC trial has been and will continue to be supported by the LATTE database. This unique database will therefore enable researchers involved in the ATAC trial to find out more information about the lasting effects of tamoxifen and anastrozole. Other researchers, not directly involved in ATAC, can apply to use annonymised LATTE data to answer other questions about breast cancer which may not be answered directly by the LATTE protocol. As such, the LATTE database will also be beneficial to the wider research community and ultimately for the care of patients with breast cancer. In future, results from LATTE study may prove to be very useful to doctors when deciding whether to prescribe anastrozole or tamoxifen to a patient, thereby moving a step closer towards personalised patient care.
Research database title
LATTE: Long-term Anastrozole vs Tamoxifen Treatment Effects
Establishment organisation
Queen Mary,University of London
Establishment organisation address
Joint Research & Development Office
24-26 Walden Street, Whitechapel
London
E1 2AN