Late sodium current inhibition in aortic stenosis

• Research type

  Research Study

• Full title

  Effect of late sodium current inhibition on MRI measured diastolic dysfunction and myocardial perfusion reserve in aortic stenosis - a proof of concept study.

• IRAS ID

  65086

• Eudract number

  2011-000111-26

• ISRCTN Number

  N/A

• Clinicaltrials.gov Identifier

  N/A

• Research summary

  The aortic valve lies between the left ventricle, the main pumping chamber of the heart, and the aorta, the main artery supplying the body. This valve can narrow, restricting the blood flow from the heart to the body, this is aortic stenosis. This eventually leads to symptoms of breathlessness, chest pain and blackouts and the only current treatment is to replace the valve. Even patients without obvious symptoms have been shown to have reduced exercise capacity when tested. The heart has to work harder to pump blood through the narrow aortic valve and as a result the heart muscle thickens. There is associated impairment of heart relaxation and the ability to increase blood flow to the heart when put under stress. The drug Ranolazine has been shown to improve the relaxation of heart and improve blood supply in patients with angina. MRI scanning can accurately measure the size, function and blood supply to the heart in a single test that does not use X-rays. This study will use MRI scanning to determine whether Ranolazine might be able to increase the blood supply to the heart and improve heart function in patients with aortic stenosis

• REC name

  London - Harrow Research Ethics Committee

• REC reference

  11/LO/0553

• Date of REC Opinion

  1 Jul 2011

• REC opinion

  Further Information Favourable Opinion