Kir 2.1 expression in patients with AF and varying BMI (version 2)
Research type
Research Study
Full title
Is there over expression of Kir 2.1 in leucocytes of patients with atrial fibrillation and high BMI compared to patients with normal BMI?
IRAS ID
150146
Contact name
Gershan Davis
Contact email
Sponsor organisation
University Hospital Aintree
Research summary
Obesity is a widespread problem and has been increasingly linked as a risk factor for atrial fibrillation (AF), a form of irregular heartbeat. Kir2.1 is a protein expressed on the cell surface of leucocytes (white blood cells). We aim to see whether patients with a high BMI and AF have an increased expression of the gene that codes for this protein compared to those with a normal BMI and AF.\n\nPatients will have a blood sample taken and a laboratory technique called polymerase chain reaction (PCR) will be used to quantify gene expression within the patient’s white blood cells.
REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
14/EE/0131
Date of REC Opinion
31 Mar 2014
REC opinion
Favourable Opinion