King's Paediatric Liver Research Biobank Renewal

• Research type

  Research Tissue Bank

• IRAS ID

  238002

• Research summary

  King's Paediatric Liver Research Biobank

• REC name

  Wales REC 4

• REC reference

  18/WA/0009

• Date of REC Opinion

  13 Feb 2018

• REC opinion

  Favourable Opinion

• Data collection arrangements

  Written consent will be taken from the parent carer or the patient as appropriate and recorded on electronic notes. Samples will be collected as excess to diagnostic requirements (no additional samples / blood tests etc needed) anonymised and stored at minus 80 degrees in a HTA designated freezer

• Research programme

  The Paediatric Liver Centre King’s College Hospital is one of the busiest in the world and the largest in Europe. One of three specialist centres in the UK it has a large catchment area covering the South East of England, Scotland, Ireland and with referrals from Europe and the middle East. Though Paediatric liver disease is relatively rare, it carries an immense burden of illness with liver transplantation often the only available treatment. Diagnoses are often elusive though with the continuing advances in the field of molecular genetics, the previously undiagnosed are now within reach and with this understanding come more effective and less invasive treatment.. The Paediatric Liver Centre at Kings has a long established diagnostic archive (established over 30 years ago), which became a formal Biobank in 2012. The Paediatric Liver Biobank has directly resulted in world class research outputs including description of the genetic bases for disorders of cholestasis, the immunological consequences of Alagille syndrome and discovery of a new variant of Alpha 1 antitrypsin deficiency *the King’s variant) Children and young people are followed by the Paediatric Liver Centre until transition to the adult centre at King’s.

• Storage license

  12378

• RTBTitle

  King's Paediatric Liver Research Biobank

• Establishment organisation

  King's College Hospital NHS Foundation Trust

• Establishment organisation address

  Denmark HIll

  London

  SE5 9PJ