Kidney transplantation and myocardial mechanics in children

  • Research type

    Research Study

  • Full title

    The effect of kidney transplantation on myocardial mechanics in children

  • IRAS ID

    206436

  • Contact name

    Owen Burgess

  • Contact email

    owen.burgess@uhbristol.nhs.uk

  • Sponsor organisation

    University Hospital Bristol NHS Foundation Trust

  • Duration of Study in the UK

    1 years, 0 months, 4 days

  • Research summary

    Chronic kidney disease (CKD) in children is associated with significant risk of cardiovascular morbidity and mortality.
    The study is investigating how children’s heart function is affected in CKD and after kidney transplantation. It is known that CKD has a detrimental effect on cardiac function, however the exact effects on the mechanics of contraction are
    not understood. Using a high quality echocardiogram (a cardiac ultrasound scan) it is possible to detect subtle changes in cardiac function by a processing method known as “strain” or “speckle tracking”. By assessing the heart in
    different imaging planes, the assessment of individual segments, motions and velocities can be performed. Children aged > 5 to < 18 years will be recruited from the Bristol Royal Hospital for Children. Comparisons of myocardial function (via strain echocardiography) will be made between 4 groups of children; 1) Healthy controls, 2) Children with CKD but not on dialysis, 3) Children with CKD undergoing a dialysis regimen and 4) Children post kidney transplant.
    The differences between the 4 groups will be analysed. Cardiac function will also be measured via traditional methods of assessment such as fractional shortening, ejection fraction and tissue Doppler velocities. Data from these traditional methods will be compared with strain data to assess their sensitivity and clinical utility in this cohort.
    Care will be taken to control the data for fluid status and arterial compliance. The data collection period will run from June 2016 to June 2017. Each participant will receive one echocardiogram as part of the study, lasting approximately one hour.

  • REC name

    South West - Central Bristol Research Ethics Committee

  • REC reference

    16/SW/0155

  • Date of REC Opinion

    8 Jun 2016

  • REC opinion

    Favourable Opinion