Ketone Esters and Cardiac Function in individuals with T2DM
Research type
Research Study
Full title
The acute effect of ketone esters on energy metabolism, cardiorespiratory fitness and cardiovascular health in people with type 2 diabetes mellitus.
IRAS ID
277602
Contact name
Maria Perissiou
Contact email
Sponsor organisation
University of Portsmouth
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 6 months, 14 days
Research summary
Type 2 diabetes mellitus (T2DM) reduces the ability of the body to use sugar as a fuel. As an alternative people with T2DM can use fat from the blood stream instead. Fat is a good store of energy, however, the body requires about 20% more oxygen to produce energy from fat compared to sugar. People with T2DM often have heart disease as well. This can lead to limited availability of oxygen in the heart muscle, which increases the workload of the heart and will impact on the ability to perform everyday tasks, such as walking up a flight of steps. Recently, it has been suggested that ketone esters (a sports drink that contains ketones) may be used as an alternative source of energy for people with diabetes as they are approximately 8% more efficient than fat. We will investigate whether these ketones can be used as a more efficient source of energy and improve how the heart works in people with T2DM. If successful, this is a relatively cheap treatment, which could be immediately implemented in people with T2DM to improve heart function and the ability to perform everyday tasks.
REC name
South Central - Berkshire Research Ethics Committee
REC reference
20/SC/0055
Date of REC Opinion
21 Feb 2020
REC opinion
Favourable Opinion