Isolation of Human Peripheral blood mononuclear cells in CHD

• Research type

  Research Study

• Full title

  Isolation of Human peripheral blood mononuclear cells in congenital heart disease

• IRAS ID

  323970

• Contact name

  Francesca Bartoli-Leonard

• Contact email

  f.bartoli-leonard@bristol.ac.uk

• Sponsor organisation

  University of Bristol

• Duration of Study in the UK

  3 years, 0 months, 1 days

• Research summary

  Isolation of PBMCs from healthy donors will be undertaken to assess the immunoactivity of xenoantigens present on the surface of xenografts used in congenital heart disease. 10mL of healthy donor blood will be taken from the participant upon enrolment into the study and the buffy coat isolated. In vitro assays will then be conducted to assess the inflammatory response to xenografts in culture. All patient samples will be destroyed after the assay has been completed.

• REC name

  North East - Newcastle & North Tyneside 1 Research Ethics Committee

• REC reference

  23/NE/0089

• Date of REC Opinion

  24 Apr 2023

• REC opinion

  Further Information Favourable Opinion