IP Nodal Study

• Research type

  Research Study

• Full title

  Intraperitoneal(IP) Nodal Study

• IRAS ID

  24186

• Contact name

  Vrunda Karanjgaokar

• Sponsor organisation

  Dept of Research & Development

• Eudract number

  2009-013875-24

• ISRCTN Number

  N/A

• Research summary

  We propose to conduct a randomised study to compare the concentration of carboplatin in the tumour as well as the pelvic / paraaortic nodal tissue after Intravenous (IV) vs Intraperitoneal (IP) chemotherapy. Our hypothesis is that IP carboplatin reaches a significantly higher concentration in the nodal tissue/tumour when administered via the IP route than the IV route. This may explain the increased progression free survival and overall survival with IP chemotherapy. We also propose to determine the p53 status of the ovarian tumour and nodes in these patients. Correlation of the p53 status to the patient's performance on carboplatin will hopefully help to increase our understanding on the predictive value of the p53 status.

• REC name

  West Midlands - Edgbaston Research Ethics Committee

• REC reference

  10/H1208/2

• Date of REC Opinion

  22 Apr 2010

• REC opinion

  Further Information Favourable Opinion