Iohexol infusion as a measure of GFR

• Research type

  Research Study

• Full title

  Investigation of a low dose Iohexol infusion for the measurement of Glomerular Filtration Rate (GFR) in adult volunteers and patients with Chronic Kidney Disease

• IRAS ID

  45435

• Contact name

  John Dixon

• Eudract number

  2010-019933-89

• ISRCTN Number

  Not applicable

• Clinicaltrials.gov Identifier

  N/A

• Research summary

  Proof-of-method study comparing a new method of measuring kidney function (Iohexol infusion) with a routine method (Iohexol clearance). A sudden deterioration in kidney function (also called 'Acute Kidney Injury', or AKI) is a common complication of serious illness and is managed in Intensive Care Units. AKI may develop very quickly and standard blood tests are poor at detecting these rapid changes in kidney function. Clearance methods; measure the time taken for a substance injected into a vein to be cleared; by the kidney and pass into the urine; these are not practical in AKI. At present, there is no accurate method of measuring kidney function in AKI. We suggest that a low dose infusion of Iohexol is a suitable method.Iohexol is a drug recommenced by the National Institute of Clinical Excellence (NICE) for measuring kidney function, but it has not been used to measure kidney function in AKI before. This is a pilot study (an experimental study that provides data for the method used in a future larger study). The aim is to compare a continuous Iohexol infusion with the Iohexol clearance method of measuring kidney function in healthy volunteers and people with varying stages of stable chronic kidney disease. If demonstrated to measure kidney function accurately we will apply this technique in future studies in patients with AKI. This will be a single-site study, occurring in a clinical area.Trial participants will be randomly allocated to receive one method first, and then return several days later for the other method. Method A involves the standard "clearance" method. Iohexol is injected into a vein, and blood and urine tests are performed over 4 hours. Method B involves an infusion of Iohexol, with blood and urine tests over 12 hours. Kidney function is calculated from these measurements. The study will last for 12 months.

• REC name

  London - Brighton & Sussex Research Ethics Committee

• REC reference

  10/H1107/24

• Date of REC Opinion

  27 May 2010

• REC opinion

  Further Information Favourable Opinion