Investigation of the Role of Semen in Embryo Implantation (IRSEI)
Research type
Research Study
Full title
Investigation of the Role of Semen in Embryo Implantation (IRSEI)
IRAS ID
161750
Contact name
Jason Kasraie
Contact email
Sponsor organisation
The Shrewsbury and Telford Hospital NHS Trust
Research summary
Embryo implantation failure is one of the major obstacles in assisted reproductive techniques (ART). It is an essential step in the journey to achieving a live birth, however it is estimated that a large proportion of failed ART is due to very early pregnancy loss shortly after embryo transfer in in-vitro fertilisation (IVF) treatments. Evidence suggests that successful embryo implantation is mediated by an appropriate uterine immune response, and it is hypothesised that semen a may play a role in triggering these uterine changes in anticipation of an implanting conceptus. Sperm preparations for use in ART usually do not include seminal plasma, and it is not known whether its absence has any effect on the endometrium and/or embryo implantation. This case-control pilot study will aim to evaluate whether natural intercourse around the time of frozen (FET/FBT) or fresh embryo transfer (fresh ET)can improve embryo implantation rates. All couples undergoing FET/FBT/fresh ET at the Shropshire and Mid-Wales Fertility Centre, Royal Shrewsbury Hospital, Shrewsbury, United Kingdom will be considered for enrolment in the study. Information about intercourse (proximity to treatment and frequency) will be obtained from study participants via a questionnaire. The main study outcomes will include the comparison of biochemical pregnancy rates, clinical pregnancy rates, and embryo implantation rates between study and control groups.
REC name
North West - Preston Research Ethics Committee
REC reference
14/NW/1273
Date of REC Opinion
22 Sep 2014
REC opinion
Favourable Opinion