Investigation into the role of GTN & RIPC in cardiac surgery
Research type
Research Study
Full title
The effect of remote ischaemic preconditioning and glyceryl trinitrate on peri-operative myocardial injury in cardiac bypass surgery patients (ERIC-GTN study)- a four arm randomised controlled trial
IRAS ID
120058
Contact name
Derek Yellon
Contact email
Sponsor organisation
University College London (UCL)
Eudract number
2013-001922-24
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 7 months, 31 days
Research summary
During cardiac surgery, ischaemia-reperfusion injury occurs when patients are weaned off heart-lung bypass machines. Remote Ischaemic Preconditioning (RIPC)is a phenomenon known to protect the heart against ischaemia-reperfusion injury. Although, this has been shown in several studies, some studies have been negative. This may be due to the interaction of various factors, one of which is the use of drugs during cardiac anaesthesia which may have a cardioprotective effect. Glyceryl TriNitrate (GTN) is a drug occasionally used in cardiac surgery. GTN may play a role in reducing ischaemia-reperfusion injury. We wish to examine the interaction between RIPC and GTN in this study.
REC name
London - Westminster Research Ethics Committee
REC reference
13/LO/0980
Date of REC Opinion
8 Jul 2013
REC opinion
Further Information Favourable Opinion