Investigating the Hypoxic Burden in Interstitial lung Disease (HYBRID)
Research type
Research Study
Full title
Investigating the Hypoxic Burden in Interstitial lung Disease (HYBRID)
IRAS ID
278239
Contact name
Dhruv Parekh
Contact email
Sponsor organisation
University of Birmingham
Duration of Study in the UK
4 years, 0 months, 0 days
Research summary
Lung diseases can cause worsening breathlessness and can prevent sufferers from carrying out everyday activities. There are only limited treatments currently available for patients with lung fibrosis. The prognosis for these patients is poor and the underlying causes of the disease are not fully understood.
In this study, we will ask patients who are suspected or known to have lung fibrosis, and age matched controls without lung fibrosis, to have their oxygen saturation levels measured over 24 hours using a portable device. We would also ask to take an urine sample, blood samples and an optional airway washing to compare findings in the lungs and blood. We would also ask the patients to perform a six minute walking test. A number of scarring diseases will be studied and the samples will be used in a number of different laboratory studies. With these samples, we will examine the communication mechanisms between cells, including the transfer of proteins and genetic material. We will also investigate the effect of microbes on development of these diseases. By investigating why certain lung cells malfunction and cause scarring, we can identify targets for new treatments, which could benefit people with lung fibrosis.REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
22/WM/0274
Date of REC Opinion
23 Jan 2023
REC opinion
Further Information Favourable Opinion