Investigating implant surface effect on osseointegration:NGA vs ModSLA
Research type
Research Study
Full title
A randomised clinical trial investigating effect of implant surface characteristic on crestal marginal bone loss, inflammatory response and aesthetic outcomes: novel gradient anodized and sandblasted large-grit acid-etched implant surfaces.
IRAS ID
329055
Contact name
Shakeel Shahdad
Contact email
Sponsor organisation
Barts Health NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
One option for replacing a missing tooth is a dental implant. This is a titanium screw which goes into the jaw to which a false tooth can be attached. For the implant to be stable and have a low risk of future disease we want bone to cover all of its surface. If there is not bone to the top of the implant, there is an increased risk of loss, poorer aesthetics due to the gum receding, and higher risk of gum disease around the implant. Therefore, for these reasons we hope to maintain bone around the top of the implant.
A new dental implant surface has been introduced: TiUltra (NobelBioCare). It is moderately rough at the bottom and becomes smoother towards the top. From our previous work, it is clear further investigation of the impact of the new NGA implant surface is needed to help ensure we provide the best results for patients. Research is needed to understand whether there is a difference between TiUltra and SLActive implants in the amount of bone grown, aesthetic result and cellular/biological response.
Currently, further research is needed to understand the inflammatory response to dental implants and how this effects dental implant outcomes. We will therefore carry out a clinical study, for patients requiring tooth replacement with an implant, and assess if there is a difference between the implants in terms of how much bone they maintain at the top of the implant. We will also assess if there is a difference between the groups in the terms of aesthetic result and immunological response.
REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
23/YH/0274
Date of REC Opinion
19 Jan 2024
REC opinion
Further Information Favourable Opinion