INTREPID

• Research type

  Research Study

• Full title

  Investigating the relevance of skin sodium and salt sensitivity of blood pressure in determining the response to anti-hypertensive drugs

• IRAS ID

  322863

• Contact name

  Ian Wilkinson

• Contact email

  ibw20@medschl.cam.ac.uk

• Sponsor organisation

  Cambridge University Hospitals NHS Foundation Trust & the University of Cambridge

• Duration of Study in the UK

  1 years, 8 months, 31 days

• Research summary

  Eating too much salt raises blood pressure and the risk of having a heart attack or stroke. We do not fully understand why salt raises blood pressure, but storage of sodium in the body, particularly in the skin, may be important. For this reason, we wish to study the link between skin sodium, blood pressure and cardiovascular risk in patients with high blood pressure, of different ethnicities, using techniques such as skin biopsy and magnetic resonance imaging (MRI). The results will provide detailed information on skin sodium storage and help us better understand the effects of blood pressure medications on these mechanisms. Ultimately, we aim to develop personalized treatment guidelines for clinical use.

• REC name

  East of England - Cambridge East Research Ethics Committee

• REC reference

  23/EE/0143

• Date of REC Opinion

  5 Jul 2023

• REC opinion

  Further Information Favourable Opinion