Intranasal Fluticasone Propionate & Azelastine in Asthma & Rhinitis
Research type
Research Study
Full title
Proof of concept study to assess downstream effects of using combined intranasal fluticasone propionate plus azelastine nasal spray on asthmatic inflammation in patients with persistent asthma and allergic rhinitis.
IRAS ID
178106
Contact name
Sunny Jabbal
Contact email
Sponsor organisation
University of Dundee
Eudract number
2015-001093-17
Duration of Study in the UK
2 years, 0 months, 3 days
Research summary
Asthma and allergic rhinitis affects approximately 10-20% of the population and therefore represents an important global health problem. About one third of patients with asthma have allergic rhinitis and vice versa. Patients who have both allergic rhinitis and asthma have a greater burden in terms of impaired quality of life.
The presence of airway twitchiness is one of the hallmarks of asthma. In this study, we aim to compare the effects of using the steroid and antihistamine (fluticasone propionate plus azelastine) combination nasal spray on airway twitchiness. We believe that using the combination nasal spray will improve airway twitchiness.
Eligible participants will be those participants with a diagnosis of allergic rhinitis and asthma who are already on asthma treatment with at least inhaled steroids and demonstrate a significant degree of airway twitchiness.REC name
East of Scotland Research Ethics Service REC 2
REC reference
16/ES/0002
Date of REC Opinion
12 Feb 2016
REC opinion
Further Information Favourable Opinion