IntHemo
Research type
Research Study
Full title
Uremic Toxins, Cardiovascular Effects and Physical Activity in Intensive Hemodialysis
IRAS ID
141581
Contact name
Sandip Mitra
Contact email
Sponsor organisation
CMFT R&D
Research summary
End-stage kidney disease patients on dialysis have high annual death rates. Kidney transplantation is the gold standard kidney replacement therapy. However, the demand for transplantation exceeds the supply of organs. Intensive haemodialysis methods have been associated with improved blood results and overall clinical outcomes compared to conventional haemodialysis methods. This might be due to more efficient removal of toxins (uremic toxins) and excess body fluid accumulation associated with kidney failure, leading to healthier blood circulation. This could translate to improved wellbeing and improved physical activity.
Our study aims to compare blood levels of marker of blood vessel injury as well as measured changes in the heart and blood vessel network (body fluid volume status, blood pressure, circulating blood speed (pulse wave velocity), heart muscle changes and small blood vessel changes) of patients undergoing different types of haemodialysis treatment. We also aim to compare the behaviour and elimination of uremic toxins and patients' degree of physical activity with these different haemodialysis treatments. For study purposes, haemodialysis treatments would be grouped in 2 groups; conventional haemodialysis (4hours, 3 times a week) and intensive haemodialysis (daily for 4 or less hours, daily overnight for 8 hours, alternate days for 4-8hours, 5 times a week from 4-8hrs). Patients prone to drops of their blood pressure during their haemodialysis treatment will form a subgroup to investigate changes in the small vessels during their dialysis treatment.
Study participants will be receiving their treatment in the participating Renal Centers. Recruitment would be over 1 year and the study period would be 2 years while they are receiving their normal haemodialysis treatment. Blood samples and measurements for the investigations outlined above and completion of a quality of life questionnaire will be performed at beginning of the study and at 6-monthly intervals.
REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
14/NW/1158
Date of REC Opinion
8 Aug 2014
REC opinion
Favourable Opinion