International Genetics Collaboration (IGC)
Research type
Research Study
Full title
International Genetics Collaboration (IGC): An observational study in the UK only, with international collaborators, to identify disease genes, genetic and COVID-19 risk factors, disease biomarkers and fundamental genetic mechanisms
IRAS ID
310045
Contact name
Henry Houlden
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
MR/S01165X/1, MRC grant MR/S01165X/1; NIHR-BRC Houlden, NIHR-BRC Houlden grant funding from UCLH; MSA Trust/ABN Houlden-Goh, MSA Trust/ABN Houlden-Goh funding
Duration of Study in the UK
5 years, 11 months, 31 days
Research summary
At UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square and through the Genomics England 100,000 Genomes Project, clinical interpretation partnership (GeCIP) we have considerable experience in genetics that has allowed us to define the causes and mechanisms of neurological disorders and risk factors.
This observational, cohort study is aimed at building and investigating ethnically diverse cohorts in the UK, and collaborating internationally with Institutes with their own approvals, to investigate children and adults with likely inherited neurological disorders or with genetic risk of disease, and undertake genomic analysis to find known and identify new disease variants, genes, risks and disease biomarkers.
This ethics application is for UK participants only, however we collaborate internationally to help compare the UK populations with other diverse populations worldwide. We will analyse a variety of biosamples that are leftover from routine investigations. If additional information or biological samples are required then participants will be invited to attend a study visit and/or will be followed up by phone. The results will yeild important information on our understanding of the role of genetics in rare and common disorders.
REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
22/NE/0080
Date of REC Opinion
20 Jul 2022
REC opinion
Further Information Favourable Opinion