Interaction between HIV drugs (NNRTIs) and Anti-platelet agents

• Research type

  Research Study

• Full title

  EFFECT OF THIENOPYRIDINE DERIVATIVES (CLOPIDOGREL AND TICLOPIDINE) ON THE DISPOSITION OF EFAVIRENZ AND NEVIRAPINE IN HIV POSITIVE PATIENTS

• IRAS ID

  10732

• Contact name

  Saye Khoo

• Sponsor organisation

  Royal Liverpool and Broadgreen University Hospital

• Eudract number

  2008-006371-67

• ISRCTN Number

  0

• Clinicaltrials.gov Identifier

  0

• Research summary

  HIV patients are living longer with a lot of them developing heart attacks or angina. This result, both from complications of HIV drugs, the HIV disease itself, or the fact that these patients are living longer and therefore heart conditions, has become more common. These patients would therefore increasingly have the need to take a combination of HIV and cardiac drugs. One group of these cardiac drugs (clopidogrel and ticlopidine) inhibit the breakdown of HIV drugs (efavirenz and nevirapine) in the body. This research aims to determine whether combining these 2 classes of drugs in patients with HIV has the potential of increasing the concentration of HIV drugs (efavirenz and nevirapine) and by implication the risk of toxicity of these drugs. There is also the potential that if these interactions were to be proven significant for it to be exploited in designing a new formulation of HIV drugs (efavirenz and nevirapine) with reduced dose of these drugs and therefore low risk of toxicity.

• REC name

  North West - Haydock Research Ethics Committee

• REC reference

  09/H1010/6

• Date of REC Opinion

  28 Aug 2009

• REC opinion

  Further Information Favourable Opinion