INSIGHT 2
Research type
Research Study
Full title
INSIGHT-2: Mechanistic Studies into Pregnancy Complications and their Impact on Maternal and Child Health
IRAS ID
326577
Contact name
Rachel Tribe
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Every expectant parent anticipates having a healthy pregnancy and baby, but sadly many pregnancies are affected by conditions such as preterm birth (PTB), preeclampsia, gestational diabetes, or a low birthweight/small for gestational age (SGA) infant. To gain greater insight into the biological mechanisms and maternal exposures that result in such pregnancy complications, there is a need to understand how complications deviate from the normal trajectory of a healthy pregnancy. Also, knowing how maternal exposures and health (pre-pregnancy and during pregnancy) and alterations in the pregnancy environment can impact on in utero fetal wellbeing and subsequent maternal, infant and child health is key if we are to develop prediction tools, preventative therapies and treatments that benefit both the mother and child.
INSIGHT-2 will recruit women from the general antenatal population and women of known higher risk for pregnancy complications such as PTB, hypertensive disorders, poor fetal growth, and gestational diabetes. We will also target women whose pregnancies have a risk factor (e.g., diabetes, obesity, metabolic syndrome, autoimmune disorders, and eczema/atopy/asthma) for later child health problems.
Through the collection of a comprehensive set of biological samples and clinical data in this cohort, we aim to explore pre-pregnancy and pregnancy factors that may contribute to disease processes and impact on fetal wellbeing and future health. This will provide a comprehensive picture of disease mechanisms in both the mother and child, aid identification of biomarkers for prediction, diagnosis and management of pregnancy complications. In addition, it will provide a valuable longitudinal study of the relationship between the in utero environment, pregnancy management and outcomes and future maternal and child health.REC name
West of Scotland REC 5
REC reference
23/WS/0114
Date of REC Opinion
1 Sep 2023
REC opinion
Further Information Favourable Opinion