Innate-like T cells in sepsis 1.0
Research type
Research Study
Full title
Innate-like T cells in sepsis (ILTIS): Implications for early diagnosis and rescue of immunosuppression\n
IRAS ID
231993
Contact name
Matthias Eberl
Contact email
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Sepsis is a potentially life-threatening condition caused by a severe infection. When someone develops sepsis, inflammation occurs not just at the site of the infection but throughout the whole body. This widespread inflammation can be very harmful.\n\nWe are recruiting a number of patients with sepsis in whom we hope to study this response of the immune system to severe infections. It is hoped that these experiments will lead to new treatments and tests that will help patients in the future.\n\nWe will be looking in detail at white blood cells that help to co-ordinate the reaction to infection. We also examine the specialised hormones in the blood (called cytokines) to see if they can be used to predict what kind of infection is present. This may lead to new tests to help patients. We will also be adding drugs to immune cells after being taken out of the body to see if we can improve their response to infection. This may lead to new treatments for patients.\n\nAll of these tests will take place on blood taken from seriously ill patients being cared for in the intensive care department. No extra needles will be used to take this blood and only 90ml (or about nine tablespoonfuls) of blood will be used over the course of a week. This amount is tiny in comparison to that take routinely for tests done on the intensive care department.COVID-19 amendment – 20/03/2020] The main changes in this amendment relate to: Specific mentioning of septic patients that are positive for COVID-19. Addition of James McLaren as Co-Investigator Including of bronchoalveolar lavage samples to study local responses in the lung
REC name
Wales REC 3
REC reference
17/WA/0253
Date of REC Opinion
20 Sep 2017
REC opinion
Favourable Opinion