Inherited Antithrombin Deficiency (v2)
Research type
Research Study
Full title
Clinical, biochemical and molecular characterisation of patients with inherited antithrombin deficiency, with investigation of the possible interactions between antithrombin and the inflammatory response
IRAS ID
284810
Contact name
Beverley Hunt
Contact email
Sponsor organisation
The University of Portsmouth
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
2 years, 5 months, 27 days
Research summary
Inherited antithrombin deficiency is associated with a significant risk for developing venous thromboembolism. An accurate diagnosis of antithrombin deficiency is crucial for antithrombotic treatment, screening other family members and the management of clinical situations such as pregnancy.
This is a cross-sectional study aiming to provide an improved understanding of the condition by further defining the genotypes of the largest cohort in the UK, who are a well-typed patient cohort. Biochemical and genetic results will be correlated with clinical manifestations. This research project will also examine links between antithrombin deficiency and inflammation by determining the levels of markers of inflammation and complement activation.Blood samples will be collected from consenting patients with inherited antithrombin deficiency who attend the Thrombosis clinics at Guy’s and St Thomas’ Hospital. The samples will be taken at the same time as routine blood samples are collected.
The sample collection stage will take approximately 18 months to complete as stable patients are only seen annually and the COVID-19 pandemic means that many appointments are currently virtual. Sample processing and results analysis will take another 18 months.REC name
North West - Liverpool Central Research Ethics Committee
REC reference
21/NW/0162
Date of REC Opinion
14 Jun 2021
REC opinion
Further Information Favourable Opinion