Influence and characterisation of excipients applied to human skin.

• Research type

  Research Study

• Full title

  In vivo profiling of model compounds in the skin using Confocal Raman Spectroscopy and their influence on the barrier function of the skin.

• IRAS ID

  205739

• Contact name

  Majella Eileen Lane

• Sponsor organisation

  University College London (UCL)

• Clinicaltrials.gov Identifier

  Z6364106/2016/05/37, Data Protection registration number

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  The human skin is one of the largest organs in the body and fights to protect us from daily threats such as UV radiation, weather changes or microbes. This protective barrier has to resist so many challenges that it may get damaged in the process hence losing its protective properties leading to aesthetic and health concerns. Thankfully, many products ranging from cosmetics to pharmaceutical products help the skin stay intact. These products maintain the barrier function of the skin.

  The aim of this study is to investigate how marketed chemical ingredients and model actives can interact with human skin. Starting from very simple formulations, the fate of these compounds in the skin will be studied using spectroscopic and tape-stripping techniques. It will help us discover new ways to protect the skin barrier and how to improve existing personal care products.

• REC name

  East of England - Cambridge South Research Ethics Committee

• REC reference

  16/EE/0448

• Date of REC Opinion

  2 Nov 2016

• REC opinion

  Further Information Favourable Opinion