Inflammation resolution in inflammatory bowel disease
Research type
Research Study
Full title
Investigation into the termination and resolution of acute inflammation in inflammatory bowel disease
IRAS ID
130764
Contact name
Daniel J B Marks
Contact email
Research summary
The term “inflammatory bowel disease“ encompasses two principal clinical disorders: ulcerative colitis and Crohn’s disease. These affect approximately 1 in every 500 people in developed populations, and their incidences are rising. They result in considerable lifelong morbidity, predisposition to colorectal cancer, increased lifetime risk of surgery, and excess mortality.
The causes of both conditions remain poorly understood, but they are characterised by chronic inflammation, primarily of the gastrointestinal tract. There is accumulating evidence that patients with inflammatory bowel disease have a perturbed initial (acute) inflammatory response.
These studies described in this application are designed to investigate the mechanisms that normally switch off, or actively resolve, acute inflammation in patients with inflammatory bowel diseases, and to determine whether abnormalities in these processes cause the disorders in question. An understanding of the cellular and molecular mechanisms that underlie the pathogeneses of the inflammatory bowel diseases will guide the development of novel targeted diagnostic and therapeutic strategies.REC name
London - Harrow Research Ethics Committee
REC reference
13/LO/1541
Date of REC Opinion
4 Nov 2013
REC opinion
Further Information Favourable Opinion