INflammation and small vessel disease (SVD) (INSVD) study
Research type
Research Study
Full title
INflammation and small vessel disease (SVD) (INSVD) study
IRAS ID
312747
Contact name
Hugh, S Markus
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust & the University of Cambridge
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
Cerebral small vessel disease (SVD) causes a quarter of strokes and it is also the second most important contributor to dementia. Despite its importance we have very few effective treatments for the disease. Academic and funder consensus statements have highlighted that a major problem to developing new treatments is a lack of understanding of the underlying physiological processes associated with small vessel disease. Early data suggests that dysregulated immune response, the reaction of the body immune system in response to infection, may play a major role in disease process by which SVD develops and progress. However, it is only by understanding in detail which components are dysregulated in the disease, and which are related to disease progression, that we can develop rational approaches to intervene therapeutically.
In this research study we will recruit study participants with SVD to characterize the abnormalities in the immune system both in the blood, and also in the brain using advanced brain imaging, and work out how these relate to disease progression. This information may allow us to design drug interventions to inhibit this inflammation and we hope improve outcome by reducing stroke and dementia.
The study will be conducted in both Cambridge, UK, and Nijmegen, Netherlands, with 100 of the 200 total participants recruited at each site, and data from both sites analysed together.REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
22/EE/0141
Date of REC Opinion
11 Jul 2022
REC opinion
Further Information Favourable Opinion