Inferior Vena Cava Collapsibility Index In Severe Sepsis v3
Research type
Research Study
Full title
Bedside ultrasound of inferior vena cava collapsibility in emergency department patients presenting with severe sepsis and septic shock.
IRAS ID
131268
Contact name
Simon Richards
Contact email
Sponsor organisation
Teesside University
Research summary
Severe sepsis is common, with over 37000 deaths in the UK annually attributed to this condition (Sepsis Trust UK).
There is debate regarding the use of invasive (central venous pressure monitoring) or non-invasive (ultrasound assessed) parameters of fluid volume status in sepsis.
To establish the role of inferior vena cava (IVC) ultrasound in guiding fluid resuscitation we first need to define the inferior vena cava collapsibility index (IVCCI) in this population of patients.
Current evidence suggests that ultrasound measurement of the IVC diameter and IVC collapsibility index may correlate with central venous pressure and can be used to assess intravascular volume status
The research question is: In adult patients with sepsis, severe sepsis, and septic shock attending the Emergency Department, what is the mean baseline Inferior Vena Cava Collapsibility Index prior to commencing fluid resuscitation.
The study is an observational cohort study using a convenience sample of patients in a university teaching hospital Emergency Department (ED)
The participants are adults attending the ED with signs of sepsis who fulfill the inclusion and exclusion criteria.
Patients consenting to take part in the trial will have an ultrasound assessment of their IVC performed and the IVCCI will be calculated.
Care will be provided in line with the published guidelines on sepsis management from the Surviving Sepsis Campaign and the College of Emergency Medicine
This study will add further information to the debate about monitoring fluids status using non invasive parameters during sepsis resuscitation. It will guide further studies looking at IVCCI guided fluid therapy in resuscitating patients with severe sepsis/septic shock.
REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
14/NE/0023
Date of REC Opinion
27 Mar 2014
REC opinion
Further Information Favourable Opinion