In vivo cone imaging in glaucoma and AMD
Research type
Research Study
Full title
Determining baseline cone-ganglion cell ratios using in vivo imaging of the retinal cone mosaic in glaucoma and AMD.
IRAS ID
116000
Contact name
Roger S. Anderson
Contact email
Sponsor organisation
Moorfields Eye Hospital NHS Foundation Trust
Research summary
Numerous post-mortem studies have shown that glaucoma is a condition that selectively kills retinal ganglion cells. Similarly, age-related macular degeneration has been shown to kill retinal photoreceptors. However, the extent to which these conditions cause death of other cell types is not well known.
Also, it is often difficult to determine if the localized density of these different cells has reduced in individual patients owing to pathology if we do not know what the baseline density was likely to have been. Using a slightly modified Heidelberg Retinal Tomograph (HRT) it is possible to greatly increase the resolution and generate localized in vivo images of the retinal cones, without the use of elaborate adaptive optics systems. We wish to image the cone mosaic at different retinal locations in patients with different retinal conditions such as glaucoma and AMD and compare the localised cone density to ganglion cell density, measured using a grating acuity test at the same locations.REC name
London - Bromley Research Ethics Committee
REC reference
13/LO/1560
Date of REC Opinion
18 Oct 2013
REC opinion
Favourable Opinion