IMPULSE V1
Research type
Research Study
Full title
IMproving PULmonary hypertension Screening by Echocardiography
IRAS ID
323768
Contact name
Daniel X Augustine
Contact email
Sponsor organisation
Royal United Hospitals Bath NHS Foundation Trust
Duration of Study in the UK
1 years, 6 months, 3 days
Research summary
Pulmonary Hypertension (high blood pressure in the blood vessels that carry blood to your lungs) is a common and sadly frequently fatal condition.
The definitive diagnostic test for pulmonary hypertension (right heart catheterisation) is invasive, and carries its own set of risks.
Transthoracic echocardiography can be used to predict probability of pulmonary hypertension but is currently an imprecise measure when assessing low and intermediate likelihood of the condition.Retrospective pilot data by our group (IMPULSE 2022) highlighted novel echo markers that may improve the detection of PH in those otherwise thought to have a low or intermediate probability of PH being present, reducing false negatives by 44% in patients with low transthoracic echocardiography probability of pulmonary hypertension as defined by the existing British Society of Echocardiography and European Society of Cardiology guidelines.
The primary goal of this prospective study is to assess the application of the IMPULSE algorithm for the detection of pulmonary hypertension in those with a low or intermediate probability of pulmonary hypertension as outlined by the European Society of Cardiology.Developing better diagnostic and predictive echocardiography in pulmonary hypertension would improve our ability to start potentially life-extending therapies sooner, and to monitor people’s response to treatment.
REC name
South Central - Berkshire Research Ethics Committee
REC reference
23/SC/0300
Date of REC Opinion
17 Aug 2023
REC opinion
Favourable Opinion