Improving therapy and outcomes in venous diseases
Research type
Research Study
Full title
An in vitro investigation into the mechanisms of action of sclerotherapy in varicose vein disease
IRAS ID
112453
Contact name
Henry F. Ashpitel
Contact email
Sponsor organisation
The Whiteley Clinic
Duration of Study in the UK
3 years, 10 months, 0 days
Research summary
Varicose veins affect a significant proportion of the adult population and are a cause of considerable discomfort to patients. Furthermore, more serious complications are possible. Despite this, much is still to be learnt regarding their pathophysiology and treatment. This research will provide insight into the molecular and cellular mechanisms resulting from the use of chemical sclerotherapy. Such treatment involves direct injection of sclerotherapy into the affected vein which is then destroyed. Its effects, however, have not been fully characterised and significant rates of clinical recurrence are seen. Varicose vein samples will be removed from patients undergoing phlebectomy operations at the Whiteley Clinic in Guildford, a clinic which specialises in the treatment of venous diseases, and provided for this research project in the Biochemistry and Physiology laboratory at the University of Surrey. The samples provided would, under normal circumstances be discarded and patients will not receive any further procedures, tests or examinations as a result of their participation. No further involvement from patients will be required following provision of samples. Analysis of the structural, biochemical and cellular changes in response to detergent molecules used for sclerotherapy will be undertaken. It is expected that findings from the current study will assist clinicians in their use of chemical sclerotherapy and improve outcomes for patients. Other treatment options, particularly mechanical sclerotherapy, will be investigated in a similar manner. It is also anticipated that this research will shed light on the pathogenesis of varicose veins.
REC name
London - Surrey Research Ethics Committee
REC reference
13/LO/0058
Date of REC Opinion
4 Feb 2013
REC opinion
Further Information Favourable Opinion