Improving prediction of ventricular arrhythmia

• Research type

  Research Study

• Full title

  Improving prediction of ventricular arrhythmia in patients with impaired left ventricular function

• IRAS ID

  89205

• Contact name

  John Chambers

• Contact email

  john.chambers@ic.ac.uk

• Sponsor organisation

  Imperial College Healthcare NHS Trust

• Research summary

  Summary of Results

  We recruited people impaired LV function, a major risk factor for ventricular arrhythmia to the study, from three hospitals in West London. As described in the science proposal, we carried out genome-wide association and epigenome-wide association using DNA from whole blood to investigate the association of common genetic variants and DNA methylation with risk of ventricular arrhythmia. However, we found there were no markers reaching either genome-wide significance (P<5x10-8) or epigenome-wide significance (P<1x10-7). There was also no evidence for an excess of association in genome-wide analyses or studies of DNA sequence variation and methylation at candidate gene.
  Our studies do not identify genetic variants or DNA methylation markers that have a strong association with risk of ventricular arrhythmia. The results suggest that common genetic variants and DNA methylation are unlikely to provide clinically relevant risk stratification in risk of ventricular arrhythmia.

• REC name

  Wales REC 4

• REC reference

  12/WA/0371

• Date of REC Opinion

  21 Dec 2012

• REC opinion

  Further Information Favourable Opinion