Impact of overweight on prognosis of diabetes mellitus
Research type
Research Database
Full title
ANGOSS
IRAS ID
96722
Contact name
Pier Luigi Constanzo
Contact email
Research summary
Impact of overweight on prognosis of diabetes mellitus
REC name
South West - Central Bristol Research Ethics Committee
REC reference
13/SW/0168
Date of REC Opinion
5 Jul 2013
REC opinion
Favourable Opinion
Data collection arrangements
A register of patients with diabetes mellitus has been established in 1995 (named ANGOSS) and patients attending the diabetes out-patient service at Hull and East Yorkshire Trust have been regularly followed-up until 2005 with collection of weight status, blood pressure, routine blood tests, smoking status, as part of normal healthcare provision.
A survival analysis will be performed to explore the impact of the weight status on the prognosis of these patients. Data on cause of mortality will be obtained through a linkage with the Office of National Statistics.
Research programme
Obesity, through insulin resistance, is a potent risk factor for Type 2 diabetes mellitus (T2DM). Obesity accounts for 80% of the overall risk of developing T2DM and appears to be the main cause of its increasing worldwide prevalence. In the UK, obesity is predicted to affect 60 per cent of adult men and 50 per cent of adult women by 2050 and, if this is true, then the prevalence of T2DM will also increase. The association between obesity and the increased risk of cardiovascular disease (CVD) is well established in the general population. However, once CVD is established, obesity seems to confer a paradoxical survival benefit. There is growing evidence showing that overweight patients with CVD survive longer than their normal-weight counterparts, an effect called the “obesity paradox”. Although obesity has been shown to account for much of the risk of developing T2DM, a similar obesity paradox may exist in T2DM too. However, results are more conflicting for diabetic patients, with studies alternating between positive and negative associations between CVD, mortality and Body Mass Index (BMI), or other weight indexes. Biased populations, inadequate study power and incomplete adjustment for comorbidities may be some of the reasons behind this inconsistency among the reported studies to date. The aim of this study is to assess the relationship of obesity, CVD and mortality in diabetes mellitus, by addressing some of the issues that might have accounted for the inconsistent results in other studies.
Research database title
Impact of overweight on prognosis of diabetes mellitus
Establishment organisation
NHS/Department of Diabetes and Endocrinology, University of Hull
Establishment organisation address
The Michael White Diabetes Centre
HS Brocklehurst Building, Hull Royal Infirmary
220-236 Anlaby Road, Hull
HU3 2RW