Impact of chronic cough on daily living activities and acute exercise
Research type
Research Study
Full title
Impact of chronic cough on activities of daily living and response to acute high-intensity exercise
IRAS ID
344527
Contact name
Oliver Price
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
1 years, 5 months, 29 days
Research summary
Chronic cough is a common and debilitating condition that affects up to 10% of the global population. The health impact of chronic cough is multifaceted and manifests both physical and psychological symptoms including syncope, chest pain, lethargy, depression and anxiety. It is also now recognised that chronic cough often leads to social isolation and may impact an individual’s ability or confidence to undertake routine daily tasks / lead an active lifestyle. Despite this, there currently remains limited evidence concerning the association between chronic cough and the ability to undertake physical activity - an intrinsically related aspect of daily living that contributes significantly to overall quality of life. In other fields of respiratory medicine (e.g., asthma and COPD), disease related impact on the capability to undertake physical activity is central to many of the most widely used quality of life assessment tools (e.g., Asthma Quality of Life Questionnaire [AQLQ] and St George’s Respiratory Questionnaire [SGRQ]), however this has yet to be systematically evaluated in the context of chronic cough.
Primary objective:
•To characterise the impact of refractory chronic cough on the ability to undertake daily activities - i.e., determine whether individuals with chronic cough exhibit impaired levels of physical activity during usual daily living when compared with healthy age, gender and BMI matched controls.Secondary objectives:
•To assess the short-term impact of high-intensity exercise on cough (i.e., determine whether an acute bout of exercise alters cough frequency and/or severity).•To explore underpinning mechanisms associated with cough frequency following an acute bout of high-intensity exercise.
•To qualitatively explore the impact of chronic cough on avoidance patterns, capability and willingness to undertake exercise.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
24/WM/0223
Date of REC Opinion
29 Oct 2024
REC opinion
Further Information Favourable Opinion