IMPAART STUDY
Research type
Research Study
Full title
A study of the IMpact of Penicillin Allergy on Antimicrobial Resistance and ouTcomes
IRAS ID
296638
Contact name
Jonathan Sandoe
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Penicillin allergy is one of the commonest reported allergies. The presence of a penicillin allergy record in a patients notes leads to the avoidance of recommended first-line penicillin antibiotics and the use of alternative non-penicillin antibiotics which can be less effective, have more side effects and have a greater propensity to drive antimicrobial resistance (AMR). Most patients with penicillin allergy records do not have a true allergy when they are tested by a specialist, so many patients are denied the best antibiotics because of an incorrect penicillin allergy record.
We plan to investigate how having a penicillin allergy impacts on treatment for patients who need antibiotics when they are hospitalised with COVID-19 and how penicillin allergy affects AMR.
Antibiotic use is the main driver of AMR, antibiotic use can also disrupt the bacteria that normally live in our guts and mouths. These bacterial communities are known as the oral and gastrointestinal (GI) microbiome and they help us digest food and prevent infections. Antibiotic use can ‘kill off’ these harmless bacteria and lead to an increase in bacteria which have genes that make them resistant to antibiotics (antibiotic resistance genes). We believe that patients with penicillin allergy are likely to have a greater number of antibiotic resistance genes in their oral and GI microbiomes. We believe that this will make it more likely that they will fail antibiotic treatment and will increase their risk of transmitting resistance to others.
Our objectives are:
1)to determine how penicillin allergy impacts on clinical outcomes in patients admitted with COVID-19
2)to find out if AMR genes in the oral microbiome of people with a penicillin allergy record are different to those without a penicillin allergy record
3)to investigate whether AMR genes are lost in patients who have an incorrect penicillin allergy label removed
REC name
London - Harrow Research Ethics Committee
REC reference
21/PR/0806
Date of REC Opinion
2 Sep 2021
REC opinion
Further Information Favourable Opinion