Immunological Ratios As Predictors Of Prognosis In Cardiac Surgery
Research type
Research Study
Full title
PLATELET-LYMPHOCYTE AND NEUTROPHIL-LYMPHOCYTE RATIOS AS PREDICTORS FOR MORTALITY AND LENGTH OF HOSPITAL STAY IN PATIENTS UNDERGOING CARDIAC SURGERY
IRAS ID
264101
Contact name
George Ramsay
Contact email
Sponsor organisation
University of Aberdeen and NHS Grampian
Duration of Study in the UK
0 years, 3 months, 1 days
Research summary
Cardiothoracic surgery carries a high risk of mortality and potentially life-changing complications. It is therefore crucial that patients are thoroughly informed of the associated risk in order to properly consent. Current scoring systems exist to give an estimate of the chances of mortality and morbidity occurring during and following cardiac surgery, but their calculation requires the results of a several tests and a significant amount of patient data. In standard practice it is often very close to the operation by the time this information has been gathered. By this time discussions of risk have usually taken place and patient has mentally prepared themselves to undergo surgery.
Other fields and studies have found that ratios calculated from pre-operative blood tests have a potential to aid prognostication. This study aims to test whether the neutrophil-lymphocyte and platelet-lymphocyte ratios can be used to predict the likelihood of death following cardiac surgery as well as complication rate following cardiac surgery. In order to trial this as a pilot study, data will be collected on all patients who have undergone cardiac surgery in Aberdeen within a 6 month period in 2018. This will include details of the preoperative blood tests from which the ratios of interest can be calculated. By use of each patients medical records it will then be possible to establish their 30 day and 90 day mortality, length of hospital stay, and other complications following surgery. This will be used to determine if these ratios have correlation to outcomes following Cardiac surgery and whether they can be used for prognostication.
REC name
North of Scotland Research Ethics Committee 2
REC reference
19/NS/0150
Date of REC Opinion
30 Oct 2019
REC opinion
Further Information Favourable Opinion