Immunohistological Research in Primary Systemic Vasculitis (IRVAS)

• Research type

  Research Study

• Full title

  Immunohistological Research in Primary Systemic Vasculitis (IRVAS)

• IRAS ID

  194217

• Contact name

  Kenneth G C Smith

• Contact email

  kgcs2@cam.ac.uk

• Sponsor organisation

  Cambridge University Teaching Hospitals NHS Foundation Trust and University of Cambridge

• Research summary

  1. To test the hypothesis that disease is driven by the plasma cells present in the inflammatory tissue\n\n2. Improve diagnostic accuracy of nasal biopsies by developing tests to identify auto-antigen specific plasma cells in situ [COVID-19 amendment – 15/04/2020] 1. Additional nasal sampling: nasal Microbiology swabs, nasal brushings and nasosorption for nasal cytokine analysis. Additional nasal sampling for disease controls under local (LA) and general anaesthesia (GA): postnasal space biopsy sampling. 3. Inguinal lymph node core-biopsy under local anaesthesia.

• REC name

  East of England - Cambridge Central Research Ethics Committee

• REC reference

  08/H0308/267

• Date of REC Opinion

  11 Nov 2008

• REC opinion

  Further Information Favourable Opinion