Immunohistochemistry of the synovium, PCL and pMFLs Ver:1.0 10/02/2016
Research type
Research Study
Full title
Immunohistochemistry of the synovium, posterior cruciate and meniscofemoral ligaments in the knee joint
IRAS ID
202552
Contact name
David Nicoll
Contact email
Sponsor organisation
TASC Tayside Medical Science Centre
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Despite recent advancements in technology and the success rates of total knee arthroplasty, 20% of patients undergoing surgery are dissatisfied because of anterior knee pain. Besides discomfort and pain, increased length of hospital discharge time and increased rehabilitation time, patients may also develop persistent postsurgical pain. The nature of the intense pain remains unclear, but neuropathic pain is thought to be the most common cause.
In this study, I plan to study surgical knee biopsy specimens (posterior cruciate and meniscofemoral ligaments with surrounding synovium) from 100 consented participants who have undergone total knee arthroplasty. I will use special stains (immunohistochemistry) to create a nerve map of the synovium, posterior cruciate and posterior meniscofemoral ligaments of the knee. Postsurgical pain management based on nerve mapping may reduce the severity of the risk of developing chronic pain after total knee arthroplasty.
This study hopes to offer an understanding of the neuropathic pain after total knee arthroplasty and may assist in pain management after surgery.REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
16/NW/0212
Date of REC Opinion
24 Mar 2016
REC opinion
Further Information Favourable Opinion